Grant R. MacGrego
Function of FNDC3 proteins in development, homeostasis and reproduction; Improved mouse models of late-onset Alzheimer’s Disease.
Function of FNDC3 proteins in development, homeostasis and reproduction; Improved mouse models of late-onset Alzheimer’s Disease.
Our research interests are in the general area of computational structural biology and biophysics. We are particularly interested in computational
Molecular pathways that ensure accurate chromosome segregation in mitosis and their intersection with embryonic development; entry and exit from quiescence
We study the Systems Biology of growth, development, birth defects and cancer. Mathematical and computational approaches are used extensively.
Our research seeks the mechanisms that underlie neurodegeneration and neuron cell death in spinal & bulbar muscular atrophy, spinocerebellar ataxia
Ubiquitin-proteasome dependent protein degradation, Proteomics, Protein-protein interactions, Structural biology, Biological mass spectrometry, Cancer, Neurodegenerative disorders
Regulation of gene expression by alternative splicing, bioinformatics, human genetic disease