John Chaput
Oligonucleotide therapeutics based on evolvable non-natural genetic polymers
My lab uses multiscale computational techniques to investigate the molecular mechanisms of disease.
Develops novel multimodal AI and computational techniques to investigate the molecular mechanisms of disease.
Studying the evolution and diversification of innate immune signaling systems using biochemical and structural methods. Interested in cyclic nucleotides and
We study 1) how glycans regulate cell-surface biology, 2) the dysregulation of glycosylation in immune aging, and 3) the development
Macromolecular assemblies in inflammation and cancer using Cryo-EM and other approaches.
Structure and function of bacterial toxins and receptors; synaptic proteins; protein complexes; protein-protein and protein-ligand interactions; X-ray crystallography; Cryo-EM
Structural biology and biochemistry of bacterial cytochrome polymers; metabolism and metabolic heterogeneity in bacterial populations and communities.
We are deciphering iron acquisition in Mycobacterium tuberculosis informed by structural and chemical biology, and proteomics. We are also working