Our research seeks the mechanisms that underlie neurodegeneration and neuron cell death in spinal & bulbar muscular atrophy, spinocerebellar ataxia type 7, Huntington’s Disease, ALS, Parkinson’s disease, and Alzheimer’s disease, and by reproducing molecular pathology in mice and in neurons, astrocytes, and skeletal muscle cells derived from human patient stem cells, we are developing therapies to treat these diseases.