Faculty participating in the Cellular & Molecular Biosciences Program
- Geoff Abbott, abbottg@uci.edu, Physiology & Biophysics
Biology and pharmacology of voltage-gated potassium channels, voltage-independent potassium channels, and ion transporters. - Bogi Andersen, bogi@uci.edu, Medicine and Biological Chemistry
Transcriptional regulation in the developmental biology of epidermis and mammary gland - Rosa Andrade, rmandra1@uci.edu, Microbiology & Molecular Genetics
Toxoplasma gondii, Entamoeba histolytica,Neglected Tropical Diseases and drug discovery. Clinical Interests: HIV and STD management. - Kavita Arora, karora@uci.edu, Developmental & Cell Biology
Drosophila development; TGF-b signal transduction; cell signaling
Regulation of protein function by covalent modification - Scott Atwood, satwood@uci.edu, Developmental & Cell Biology
Cell fate decisions in skin cancer, skin and hair follicle development, and stem cells. - Pierre Baldi, pfbaldi@uci.edu, Computer Science, Biological Chemistry, and Development & Cell Biology
Bioinformatics, computational biology, probabilistic modeling, and machine learning - Tallie Z. Baram, tallie@uci.edu, Physiology & Biophysics
Epigenetic mechanisms in brain plasticity; stress, epilepsy, learning and memory - Lee Bardwell, bardwell@uci.edu, Developmental and Cell Biology
Intracellular signaling in development and disease - Kevin Beier, kbeier@uci.edu, Physiology & Biophysics
Identifying how experience modulates activity dynamics in neural circuits, both acutely and chronically - Claudia Benavente, claudia.benavente@uci.edu, Developmental & Cell Biology
Understanding epigenetic deregulation in pediatric cancer tumorigenesis - Michael W. Berns, mwberns@uci.edu, Developmental & Cell Biology and Surgery
Laser microsurgery of cells, embryos, and tissues - Elizabeth N. Bess, elizabeth.bess@uci.edu, Molecular Biology and Biochemistry
Uncovering chemical reactions encoded in the gut microbiome to understand and treat human disease - Bruce Blumberg, blumberg@uci.edu, Developmental & Cell Biology
Gene regulation by nuclear hormone receptors in vertebrate development & adult physiology Epigenomic analysis of gene-environment interactions - Alexander Boiko, aboiko@uci.edu, Molecular Biology and Biochemistry
Isolation and Characterization of Tumor Initiating Cells from melanoma patients. - Emiliana Borrelli, borrelli@uci.edu, Microbiology & Molecular Genetics and Pharmacology
Dopaminergic system, with particular focus on dopamine D2 receptors - Daniela Bota, dbota@uci.edu, Neurology and Pathology & Laboratory Medicine
The mechanisms of chemotherapy-induced cognitive damage, and differential mechanisms governing glioma stem cell versus neural stem cell differentiation - Michael J. Buchmeier, m.buchmeier@uci.edu, Molecular Biology & Biochemistry and Medicine
Viral biology and pathogenesis, structural and functional proteomics of viruses, and biodefense related pathobiology - Remi Buisson, rbuisson@uci.edu, Biological Chemistry
Genomic instability, DNA repair and mutagenesis in cancer - Michael D. Cahalan, mcahalan@uci.edu, Physiology & Biophysics
Ion channels in the nervous and immune systems - Anne L. Calof, alcalof@uci.edu, Anatomy & Neurobiology and Developmental & Cell Biology
Regulation of stem cells in development and regeneration; genomic strategies for understanding the etiology and treatment of human neurodevelopmental disorders using transgenic mouse models - Jefferson Y. Chan, jchan@uci.edu, Pathology & Laboratory Medicine
Regulation of genes associated with oxidative stress - John Chaput, jchaput@uci.edu, Molecular Biology & Biochemistry
Expanding the concepts of heredity and evolution to artificial genetic polymers with backbone structures that are distinct from those found in nature - Dongbao Chen, dongbaoc@uci.edu, Obstetrics & Gynecology and Pathology & Laboratory Medicine
Angiogenesis and perinatal vascular biology - Phang Lang Chen, plchen@uci.edu, Cancer Biology and Biological Chemistry
Critical role of tumor suppressor genes in the genesis and progression of cancer - Steven Chessler, s.chessler@uci.edu, Medicine and Pathology & Laboratory Medicine
Cellular and molecular mechanisms underlying insulin secretion, pancreatic islet function, and beta cell failure in diabetes. - Ken W.-Y. Cho, kwcho@uci.edu, Developmental & Cell Biology
Molecular mechanisms of axis specification in Xenopus - Olivier Cinquin, olivier.cinquin@uci.edu , Developmental & Cell Biology
Systems biology of cell differentiation - Olivier Civelli, ocivelli@uci.edu, Pharmacology and Developmental & Cell Biology
Molecular neurobiology, G protein-coupled receptors, peptide neurotransmitters - Melanie Cocco, mcocco@uci.edu, Molecular Biology & Biochemistry
NMR spectroscopy, DNA-binding proteins, membrane proteins, cancer - Xing Dai, xdai@uci.edu, Biological Chemistry
Skin and mammary stem cells, Wnt signaling, chromatin, transcription - Michael Demetriou, mdemetri@uci.edu, Neurology and Microbiology & Molecular Genetics
Molecular biology and glycobiology of T cell dysfunction in autoimmune demyelinating disease - Peter Donovan, pdonovan@uci.edu, Biological Chemistry, Professor of Developmental & Cell Biology
Molecular genetics of germ cell and stem cell development - Timothy Downing, thdownin@uci.edu, Microbiology & Molecular Genetics
Stem cell and tissue engineering, regenerative biology, cell reprogramming, epigenomics, mechanobiology - Aimee Edinger, aedinger@uci.edu, Developmental and Cell Biology
Cancer biology and therapy, intracellular trafficking, obesity, drug development and delivery - Robert Edwards, redwards@uci.edu, Pathology & Laboratory Medicine
Development of colitis and colon cancer using a G-protein mouse model of inflammatory bowel disease - Dae Seok Eom, dseom@uci.edu, Developmental & Cell Biology
Specialized cellular projection-mediated cell-to-cell signaling - Mark J. Fisher, mfisher@uci.edu, Pathology & Laboratory Medicine.
Mechanisms of cerebrovascular stroke - Angela Fleischman, agf@uci.edu, Medicine and Biological Chemistry
Hematopoietic stem cell biology and leukemia - Donald Forthal, dnfortha@uci.edu, Medicine, Molecular Biology & Biochemistry
Interactions between antibodies and Fc receptors and the role of these interactions in preventing, controlling or enhancing infection with HIV and related lentiviruses. - David A. Fruman, dfruman@uci.edu, Molecular Biology & Biochemistry
Signal transduction in lymphocytes - Anand Ganesan, aganesan@uci.edu, Dermatology and Biological Chemistry
Identify the key molecular regulators of melanin production, melanoma cell survival, and melanoma chemoresistance in human cells - Paul Gershon, pgershon@uci.edu, Molecular Biology & Biochemistry
mRNA transcription and modification - Charles G. Glabe, cglabe@uci.edu, Molecular Biology & Biochemistry
Amyloid Ab peptide in Alzheimer’s pathogenesis; gamete recognition - Alan L. Goldin, agoldin@uci.edu, Microbiology & Molecular Genetics
Molecular analysis of ion channel function - Shane Gonen, gonens@uci.edu, Molecular Biology & Biochemistry
Electron cryo-microscopy (Cryo-EM); Membrane proteins; Protein complexes; Computational protein design - Steven A. Goldstein, sgoldst2@uci.edu, Physiology & Biophysics
Ion channels in health and disease - Celia Goulding, celia.goulding@uci.edu, Molecular Biology & Biochemistry
Structural and biochemical studies of molecular assemblies in Mycobacterium tuberculosis - Michael Green, m.green@uci.edu, Molecular Biology & Biochemistry and Chemistry
Structure-function relationships in metalloproteins, protein engineering, and biological C-H bond activation - Steven Gross, gonens@uci.edu, Developmental & Cell Biology
Laser tweezers; in vivo study of molecular motors - Klemens Hertel, khertel@uci.edu, Microbiology & Molecular Genetics
Regulation of gene expression by alternative splicin - Allon Hochbaum, hochbaum@uci.edu, Molecular Biology and Biochemistry
Biological and bioinspired materials; chemical and biophysical regulation of bacterial biofilms; supramolecular protein assembly - Todd Holmes, tholmes@uci.edu, Physiology & Biophysics
Human neurodegenerative disease mechanisms in transgenic animals - Naoto Hoshi, nhoshi@uci.edu, Pharmacology and Physiology and Biophysics
M-type potassium ion channel regulation through protein complex - Yilin Hu, yilinh@uci.edu, Molecular Biology and Biochemistry Biofuel, activation and reduction of carbon dioxide, structure & function of metalloenzymes involved in methanogenesis, photosynthesis and nitrogen fixation
- Lan Huang, lanhuang@uci.edu, Physiology & Biophysics
Defining the structure and function of protein complexes using cross-linking mass spectrometry and integrative modeling, Proteasomal biology, Ubiquitination, Chemical biology, Quantitative Proteomics, Protein-protein interactions; Regulation of the ubiquitin-proteasome system. - Christopher C.W. Hughes, cchughes@uci.edu, Molecular Biology & Biochemistry
Molecular biology of developmental and tumor angiogenesis - Matt Inlay, minlay@uci.edu, Molecular Biology & Biochemistry
Molecular mechanisms regulating developmental fate decisions in embryonic and adult hematopoiesis in mouse and humans. - Autumn S. Ivy, aivy@uci.edu, Physiology & Biophysics
Role of exercise-induced chromatin modifications in brain plasticity and neural function, early-life periods of brain maturation. - Rongsheng Jin, r.jin@uci.edu, Physiology & Biophysics
Structure and function of synaptic proteins; neurotoxins and receptors; protein complexes; protein-protein and protein-ligand interactions; X-ray crystallography. - Peter Kaiser, pkaiser@uci.edu, Biological Chemistry
Cell cycle control; regulation of proteins by ubiquitination - Christina Kenney, mkenney@uci.edu, Pathology
Age-related macular degeneration, AMD, mitochondrial genetics, Keratoconus, KC - Kai Kessenbrock, kkessenb@uci.edu, Biological Chemistry
Microenvironmental Control of Stem Cells and Cancer - Philip Kiser, pkiser@uci.edu, Physiology & Biophysics
Physiology and structural biology of the first steps of vertebrate vision, retinoid and carotenoid metabolism, retinal disease and therapeutics. - Mei Kong, meik1@uci.edu, Molecular Biology & Biochemistry
Nutritional microenvironment in tumor development and drug response, metabolism and epigenetics, protein phosphatase regulation in diabetes and obesity - Young Jik Kwon, kwonyj@uci.edu, Molecular Biology & Biochemistry, Pharmaceutical Sciences, Chemical Engineering & Materials Science, and Biomedical Engineering
Cancer-targeted therapeutics, Engineered viral vectors for gene therapy, Cancer Vaccine - Arthur D. Lander, adlander@uci.edu, Developmental & Cell Biology
Mechanisms of growth factor action; extracellular matrix; developmental neurobiology; systems biology - Thomas E. Lane, tlane@uci.edu, Molecular Biology & Biochemistry
Defining the molecular and cellular mechanisms that contribute to both host defense and disease following viral infection of the central nervous system (CNS)
ARRIVING January 1, 2020 - Devon Lawson, dalawson@uci.edu, Physiology & Biophysics
Mechanisms of Cancer Metastasis - Wei Ling Lau, wllau@uci.edu, Physiology & Biophysics
Vascular calcification, cerebral microbleeds, and chronic inflammation in chronic kidney disease - Chang Liu, ccl@uci.edu, Biomedical Engineering, Chemistry, and Molecular Biology & Biochemistry
Engineered genetic systems for rapid evolution, chemical biology, synthetic biology, and cell biology - Haoping Liu, h4liu@uci.edu, Biological Chemistry
MAP kinase signal transduction; dimorphic regulation in yeast - Melissa Lodoen, mlodoen@uci.edu, Molecular Biology & Biochemistry
Innate immunity, host-microbe interactions, and immune evasion by Toxoplasma gondii - Ulrike Luderer, uluderer@uci.edu, Medicine, Developmental & Cell Biology and Public Health
Reproductive toxicology, developmental toxicology - Ray Luo, rluo@uci.edu, Molecular Biology & Biochemistry
Computational structural biology, biomolecular recognition and biosynthesis, cancer biology, synthetic biology - Andrej Luptak, aluptak@uci.edu, Pharmaceutical Sciences, Chemistry, and Molecular Biology and Biochemistry
RNA biology and chemistry - Grant MacGregor, gmacg@uci.edu, Developmental & Cell Biology
Gametogenesis in the mouse - Francesco Marangoni, fmarango@uci.edu, Physiology & Biophysics
Identify immune regulatory mechanisms within tumors using functional intravital microscopy (F-IVM), and to counteract them to improve the efficacy of immunotherapies - Rachel Martin, rachel.martin@uci.edu, Molecular Biology & Biochemistry
Solid state NMR, protein structure, membrane proteins, physical chemistry, chemical biology - Selma Masri, smasri@uci.edu, Biological Chemistry
Circadian Clock disruption and its links to cancer, stem cell biology and metabolism - Michael McClelland, mmcclell@uci.edu, Microbiology and Molecular Genetics Evolution of Salmonella pathogenesis; bacterial therapy for cancer; cancer genomics and prognostic
- Reginald “Reggie” McNulty, rmcnulty@uci.edu, Molecular Biology & BiochemistryMacromolecular assemblies in inflammation and cancer using Cryo-EM and other approaches
- Alexander McPherson, amcphers@uci.edu, Molecular Biology & BiochemistryMacromolecular crystal growth; X-ray diffraction analysis of protein, nucleic acid and virus crystals; Atomic Force Microscopy studies of biological structures, immunoglobulin structure, virus structure and assembly
- Dan Mercola, dmercola@uci.edu, Pathology & Laboratory MedicineTranslational research in prostatic cancer
- Ilhem Messaoudi, imessaou@uci.edu, Molecular Biology & BiochemistryViral pathogenesis, vaccine development, microbiome, modulation of immunity by nutrition
- Edwin S. Monuki, emonuki@uci.edu, Pathology & Laboratory Medicine and Developmental & Cell BiologyCerebral cortex development and disease
- Naomi Morrissette, nmorriss@uci.edu, Molecular Biology & BiochemistryGenetic, cell biological and structure-function studies of tubulin and microbutules in Apicomplexan parasites
- Ali Mortazavi, ali.mortazavi@uci.edu, Developmental & Cell BiologyApplications of genomics, computation, and sequencing technologies to the analysis of transcriptional regulation in development
- R. Michael Mulligan, rmmullig@uci.edu, Developmental & Cell Biology and Ecology & Evolutionary BiologyRNA editing in plant mitochondria and chloroplast
- Edward L. Nelson, enelson@uci.edu, Medicine and Molecular Biology & BiochemistryTumor immunology, dendritic cell biology, and anti-tumor immunotherapeutics
- Michael Parsons, mparson1@uci.edu, Developmental and Cell Biology
Role of stem cells and facultative progenitors in development and regeneration of insulin-producing cells - Medha Pathak, medhap@uci.edu, Physiology & Biophysics
How mechanical forces shape neural stem cells behavior in vitro and in vivo; Transduction of mechanical forces by the Piezo1 ion channel - Nicholas Pannunzio, nrpann@uci.edu, Biological Chemistry
Understanding how internal and external sources of DNA damage lead to oncogenic genome rearrangements in B cell malignancies - Eric Perlman, epearlma@uci.edu, Ophthalmology and Physiology & Biophysics
Regulatory role of neutrophils in bacterial and fungal infections - Maksim Plikus, plikus@uci.edu, Developmental & Cell Biology
Stem cells and stem cell niche, Regeneration of tissues and organs, Biological pattern formation, Self-organization, Skin and hair follicles, Adipose tissue, WNT and BMP signaling pathways - Thomas L. Poulos, poulos@uci.edu, Molecular Biology & Biochemistry and Physiology & Biophysics
Protein engineering and crystallography - Jennifer Prescher, jpresche@uci.edu, Chemistry, Molecular Biology & Biochemistry, and Pharmaceutical Sciences
Probing biological systems with chemical tools and noninvasive imaging - Feng Qiao, qiao@uci.edu, Biological Chemistry
Telomeres & telomerase and their roles in cancer and stem cell diseases; Structural, biochemical and molecular genetic analyses of nucleoprotein assemblies - Olga V. Razorenova, olgar@uci.edu, Molecular Biology & Biochemistry
Internal (oncogenes/tumor suppressor genes) and external (tumor microenvironment)
factors regulating tumor progression and metastasis - Elizabeth Read, elread@uci.edu, Molecular Biology & Biochemistry
Computational systems biology and dynamics of adaptive immunity. - Markus Ribbe, mribbe@uci.edu, Molecular Biology & Biochemistry, and Chemistry Director, Biofuel Innovation Center
Biofuel, artificial enzymes, assembly & function of enzymes containing complex metal cofactors - Hamid M. Said , hmsaid@uci.edu Medicine and Physiology & Biophysics
Cellular and molecular aspects of intestinal transport of water-soluble vitamins - Suzanne B. Sandmeyer, sbsandme@uci.edu, Biological ChemistryMolecular genetics of a position-specific yeast retrovirus-like element
- Rozanne M. Sandri-Goldin, rmsandri@uci.edu,Microbiology & Molecular Genetics
Regulatory functions of a post-transcriptionally acting herpes virus protein - Paolo Sassone-Corsi, psc@uci.edu, Microbiology & Molecular Genetics
Mechanisms of signal transduction able to modulate nuclear functions and, in particular gene expression, chromatin remodeling and epigenetic control - Tom Schilling, tschilli@uci.edu, Developmental & Cell Biology
Skeletal and neural patterning; mutational analysis and molecular genetics in the zebrafish - Bert L. Semler, blsemler@uci.edu, Microbiology & Molecular Genetics
Replication of picornavirus RNAs; RNA-protein and protein-protein interactions - Marcus Seldin, mseldin@uci.edu, Biological Chemistry
Systems genetics approaches to understand metabolism and physiology with a special emphasis on mechanisms of tissue-tissue communication - Donald F. Senear, dfsenear@uci.edu, Molecular Biology & Biochemistry
Interactions of proteins and DNA in transcriptional regulation - Xiaoyu Shi, xiaoyu.shi@ucsf.edu, Developmental & Cell Biology
Interested in developing new in situ multiomics methods, by leveraging Super-resolution Microscopy, Expansion Microscopy and multiomics - Yongsheng Shi, yongshes@uci.edu, Microbiology & Molecular Genetics The role of post-transcriptional gene regulation in stem cells and cancer
- Albert Siryaporn, asirya@uci.edu, Physics & Astronomy and Molecular Biology & Biochemistry Bacterial pathogenesis, mechanical signal transduction, and biofilm development
- Robert Spitale, rspitale@uci.edu, Molecular Biology & Biochemistry
Focused at understanding how the flow of genetic information is controlled inside cells and altered to result in disease phenotypes - Christine Suetterlin, suetterc@uci.edu, Developmental & Cell Biology
Golgi and centrosome regulation, host pathogen interactions - Ming Tan, mingt@uci.edu, Microbiology & Molecular Genetics, and Medicine
Chlamydia infections: Gene regulation and host pathogen interactions - Andrea J. Tenner, atenner@uci.edu, Molecular Biology & Biochemistry and Pathology & Laboratory Medicine
Complement: Molecular basis of neuroinflammation; Alzheimer’s disease - Leslie M. Thompson, lmthomps@uci.edu, Psychiatry, Biological Chemistry, and Neurobiology & Behavior
Molecular and biochemical mechanisms of disease pathogenesis and therapeutic approaches to human neurodegenerative disease - Katherine L Thompson-Peer, ktpeer@uci.edu, Developmental & Cell Biology
Neuronal regeneration after injury; dendrite regeneration - Roberto Tinoco, rtinoco@uci.edu, Molecular Biology & Biochemistry
Adaptive Immune Responses; cellular and molecular mechanisms that promote T cell exhaustion during chronic viral infection and cancer - Francesco Tombola, ftombola@uci.edu, Physiology & Biophysics
Electrical and chemical sensing in excitable cells, VSD-containing ion channels and enzymes - Sheryl Tsai, sctsai@uci.edu, Molecular Biology & Biochemistry
Drug design and crystallography of protein complexes - Armando Villalta, armando.villalta@uci.edu, Physiology and Biophysics
Immune cell and organ system interactions that promote tissue injury and repair - Craig Walsh, cwalsh@uci.edu, Molecular Biology & Biochemistry
Apoptotic mechanisms in immune development and homeostasis - Ping Wang, phwang@uci.edu, Medicine, Biological Chemistry, Physiology & Biophysics, and Pathology & Laboratory Medicine
Molecular hormone actions in diseases and stem cells - Wenqi Wang, wenqiw6@uci.edu, Developmental & Cell Biology
Signaling network in organ size control and cancer development - Rahul Warrior, rwarrior@uci.edu, Developmental & Cell Biology
Developmental regulation of proteoglycan biosynthesis; Transcriptional response to BMP growth factor signaling - Marian L. Waterman, mlwaterm@uci.edu, Microbiology & Molecular Genetics
Regulation of gene expression in development and cancer - Gregory Weiss, gweiss@uci.edu, Chemistry and Molecular Biology & Biochemistry and Pharmaceutical Sciences
Engineering and dissection of protein structure and function - Katrine Whiteson, katrine@uci.edu, Molecular Biology & Biochemistry
Metagenomics, metabolomics and community culture models of host-associated microbial and viral communities in health and disease; human microbiome; microbial ecology. - Zeba Wunderlich, zeba@uci.edu, Developmental and Cell Biology
Experimental and computational approaches to understanding regulatory DNA in animals. - Xiaohui Xie, xhx@ics.uci.edu, Computer Science and Developmental & Cell Biology
Computational biology, bioinformatics, and genomics - Qin Yang, qiny3@uci.edu, Medicine and Physiology & Biophysics
Cellular and molecular mechanisms for insulin resistance and energy expenditure in obesity and type 2 diabetes - Kyoko Yokomori, kyokomor@uci.edu, Biological Chemistry,
- Chromatin Structure Regulation in Human ES Cells; Gene expression and chromatin structure
- Michael Zaragoza, mzaragoz@uci.edu, Biological Chemistry and PediatricsMolecular mechanisms of inherited cardiovascular diseases
- Weian Zhao, weianz@uci.edu, Biological Chemistrycancer and developmental mechanobiology, stem cell and immuno-therapy, and microbial genetics
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