Faculty participating in the Cellular & Molecular Biosciences Program
- Geoff Abbott, firstname.lastname@example.org, Physiology & Biophysics
Biology and pharmacology of voltage-gated potassium channels, voltage-independent potassium channels, and ion transporters.
- Lauren Veronica Albrecht, email@example.com, Developmental & Cell Biology
Discovery of novel molecular pathways driving cell growth and tissue homeostasis in health and in disease.
- Bogi Andersen, firstname.lastname@example.org, Biological Chemistry
The goal of my research is to understand the role of the circadian clock in skin and the gene-regulatory mechanisms underlying epidermal differentiation and repair.
- Rosa M. Andrade, email@example.com, Microbiology & Molecular Genetics
Understanding the Redox homeostasis of Toxoplasma gondii to find new therapeutic targets
- Kavita Arora, firstname.lastname@example.org, Developmental & Cell Biology
We are interested in the diverse cellular responses triggered by TGF-ß signaling proteins in development. Recent areas of study are: the neuroendocrine control of developmental timing, and the regulation of metabolism by TGF-ß ligands.
- Scott Atwood, email@example.com, Developmental & Cell Biology
The Atwood lab is interested in how stem cell heterogeneity drives epidermal homeostasis and disease using models of skin development and cancer.
- Tallie Z. Baram, firstname.lastname@example.org, Physiology & Biophysics
Epigenetic mechanisms in brain plasticity; stress, epilepsy, learning and memory
- Lee Bardwell, email@example.com, Developmental & Cell Biology
We study cancer signaling pathways and other disease-relevant regulatory pathways, focusing on protein kinases, scaffold proteins, and transcription factors. We also do some computational/mathematical modeling.
- Kevin T. Beier, firstname.lastname@example.org, Physiology & Biophysics
Molecular and neural circuit basis of mental illness, substance use disorders, Alzheimer’s disease – genetic/epigenetic individual vulnerability factor identification
- Claudia Benavente, email@example.com, Developmental & Cell Biology
Identifying therapeutic vulnerabilities in solid malignancies harboring RB1 mutations, with special emphasis on epigenetics.
- Elizabeth N. Bess, firstname.lastname@example.org, Molecular Biology & Biochemistry
Uncovering chemical reactions encoded in the gut microbiome to understand and treat human disease
- Bruce Blumberg, email@example.com, Developmental & Cell Biology
My lab focuses on multi-‘omic analyses of gene environment interactions important for development, adult physiology and disease predisposition using in vitro and in vivo models.
- Emiliana Borrelli, firstname.lastname@example.org, Microbiology & Molecular Genetics
Involvement of dopamine in addiction and in neurological and psychiatric disorders
- Daniela Bota, email@example.com, Pathology & Laboratory Medicine
To understand the biology and to develop new translational approaches for neurologic malignancies and cancer-related cognitive impairments.
- Remi Buisson, firstname.lastname@example.org, Biological Chemistry
Genomic instability, DNA repair and mutagenesis in cancer
- Thomas Burke, email@example.com, Microbiology & Molecular Genetics
We study bacterial pathogenesis and the host innate immune response to infection. We’re also targeting innate immunity as a strategy to treat cancer.
- Minji Byun, firstname.lastname@example.org, Microbiology & Molecular Genetics
Epigenetic modulator dysfunction in human developmental and immune disorders
- Anne L. Calof, email@example.com, Developmental & Cell Biology
My laboratory uses genetic model organisms to study how stem cell behaviors and gene expression changes both direct normal development and contribute to the etiology of syndromic and non-syndromic birth defects.
- John Chaput, firstname.lastname@example.org, Molecular Biology & Biochemistry, Biological Chemistry
Oligonucleotide therapeutics based on evolvable non-natural genetic polymers
- Dongbao Chen, email@example.com, Pathology & Laboratory Medicine
Uterine and placental hemodynamics, perinatal vascular biology, pregnancy complications
- Phang-Lang Chen, firstname.lastname@example.org, Biological Chemistry
Dissecting DNA damage response pathway
- Ken W.Y. Cho, email@example.com, Developmental & Cell Biology
Using genomics, we study how early cellular differentiation events, particularly in the endodermal lineage leading to an animal’s gut and extraembryonic structures, are programmed.
- Olivier Civelli, firstname.lastname@example.org, Developmental & Cell Biology
Molecular neurobiology, G protein-coupled receptors, peptide neurotransmitters
- Melanie Cocco, email@example.com, Molecular Biology & Biochemistry
Biophysical and Structural Studies of Membrane and DNA-Binding Proteins
- Xing Dai, firstname.lastname@example.org, Biological Chemistry
Intrinsic and microenvironmental control of skin and mammary epithelial stem cell function in development and repair/regeneration, and how such control mechanisms go awry in disease and aging.
- Fangyuan Ding, email@example.com, Developmental & Cell Biology
RNA biology and engineering, synthetic biology, single molecule imaging and quantification
- Timothy Lamont Downing, firstname.lastname@example.org, Microbiology & Molecular Genetics
The Downing Lab explores new and innovative approaches to cell and tissue engineering. We are particularly interested in understanding how the genome is regulated through non-sequence-based changes to DNA (epigenetics) during healthy tissue development and disease progression.
- Nir Drayman, email@example.com, Molecular Biology & Biochemistry
Studies how cell-to-cell variability affects viral infection outcomes using technologies such as live-imaging, machine learning, single-cell RNA-sequencing and microfluidics
- Aimee Edinger, firstname.lastname@example.org, Developmental & Cell Biology
Understanding endolysosomal trafficking and sphingolipid biology and translating these discoveries into new therapies for cancer, obesity, and other diseases
- Asuka Eguchi, email@example.com, Physiology & Biophysics
We study the pathogenic progression of genetic cardiomyopathies to develop therapeutic strategies for heart failure. Human iPSCs provide the disease model to study disease phenotypes.
- Dae Seok Eom, firstname.lastname@example.org, Developmental & Cell Biology
Intercellular signaling in stem cells and tissue remodeling
- Philip L. Felgner, email@example.com, Physiology & Biophysics
The UCI Vaccine R&D Center is supported by the NIH to develop vaccine and vaccine adjuvants for infectious diseases. There is an emphasis on Pandemic Preparedness. The lab is equiped with all of the science, equipment and know-how to construct and test lipid nanoparticle (LNP) vaccines of the kind that are in the COVID vaccines from Moderna and BioNTech. The same mRNA/LNP technology developed for the COVID vaccine is also applicable to gene therapy and gene editing.
- Mark Fisher, firstname.lastname@example.org, Pathology & Laboratory Medicine
Stroke, vascular neurobiology, blood-brain barrier, cerebral microvascular disease
- Angela Fleischman, email@example.com, Biological Chemistry
Role of inflammation in the development of hematologic malignancies.
- Don Forthal, firstname.lastname@example.org, Molecular Biology & Biochemistry, Pathology & Laboratory Medicine
My laboratory focuses on understanding how antibodies interact with cells bearing Fc receptors (such as macrophages, monocytes, NK cells) and how such interactions affect viral infection. We are interested both in ways that antibodies protect from infection and in ways that antibodies participate in immunopathology.
- David Fruman, email@example.com, Molecular Biology & Biochemistry
The focus of research in the Fruman Lab is targeted therapies to modulate signaling and metabolism in lymphocytes and leukemia cells.
- Anand K. Ganesan, firstname.lastname@example.org, Biological Chemistry
Our work understands how melanocytes respond to environmental cues in the context of skin disease and cancer.
- Paul Gershon, email@example.com, Molecular Biology & Biochemistry
mRNA transcription and modification
- Shane Gonen, firstname.lastname@example.org, Molecular Biology & Biochemistry
The Gonen lab studies proteins implicated in disease by cryogenic electron microscopy, biochemistry and computational modelling
- Steve A. N. Goldstein, email@example.com, Physiology & Biophysics
Ion channels in the heart, innate immune system, and nervous system in health and disease
- Celia Goulding, firstname.lastname@example.org, Molecular Biology & Biochemistry
We are deciphering iron acquisition in Mycobacterium tuberculosis informed by structural and chemical biology, and proteomics. We are also working on contact-dependent growth inhibition systems (CDI), and the structural basis of its mechanism of action.
- Michael Green, email@example.com, Molecular Biology & Biochemistry
Structure-function relationships in metalloproteins, protein engineering, and biological C-H bond activation
- Matthew Griffin, firstname.lastname@example.org, Molecular Biology & Biochemistry
Our lab focuses on understanding the molecular mechanisms underlying host-microbiota interactions during cancer progression and treatment.
- Steven Gross, email@example.com, Developmental & Cell Biology
I study how molecular motors function and are regulated, and also a new pathway in the innate immune system to kill bacteria.
- Chris Halbrook, firstname.lastname@example.org, Molecular Biology & Biochemistry
My lab is primarily focused on understanding mechanisms that support cancer development and resistance to therapy.
- Klemens Hertel, email@example.com, Microbiology & Molecular Genetics
Regulation of gene expression by alternative splicing, bioinformatics, human genetic disease
- Michael Hicks, firstname.lastname@example.org, Physiology & Biophysics, Developmental & Cell Biology
Stem cell and gene therapies for skeletal muscle regeneration
- Allon Hochbaum, email@example.com, Molecular Biology & Biochemistry
Structural biology and biochemistry of bacterial cytochrome polymers; metabolism and metabolic heterogeneity in bacterial populations and communities.
- Todd C. Holmes, firstname.lastname@example.org, Physiology & Biophysics
We study non-image forming visual mechanisms controlling arousal, phototaxis/light avoidance, time-of-day information behaviors in Drosophila (Fogle et al., 2011, Science; Ni, Baik et al., 2017, Nature).
- Naoto Hoshi, email@example.com, Physiology & Biophysics
Regulation and pathological roles of a voltage-gated potassium channel, Kv7 channel
- Yilin Hu, firstname.lastname@example.org, Molecular Biology & Biochemistry Biofuel, activation and reduction of carbon dioxide, structure & function of metalloenzymes involved in methanogenesis, photosynthesis and nitrogen fixation
- Lan Huang, email@example.com, Physiology & Biophysics
Ubiquitin-proteasome dependent protein degradation, Proteomics, Protein-protein interactions, Structural biology, Biological mass spectrometry, Cancer, Neurodegenerative disorders
- Christopher C.W. Hughes, firstname.lastname@example.org, Molecular Biology & Biochemistry
Vascular biology with a focus on microphysiological systems, also called organ-on-chip technology. We work on cancer, neurological diseases, diabetes and vascular malformations
- Matthew Arthur Kalani Inlay, email@example.com, Molecular Biology & Biochemistry
The biology, development, and therapeutic use of hematopoietic stem cells in blood and marrow transplantation, and the role of the immune system in graft tolerance and graft-versus-host disease.
- Cholsoon Jang, firstname.lastname@example.org , Biological Chemistry
Nutrition metabolism, metabolic diseases, mass spectrometry
- Rongsheng Jin, email@example.com, Physiology & Biophysics
Structure and function of bacterial toxins and receptors; synaptic proteins; protein complexes; protein-protein and protein-ligand interactions; X-ray crystallography; Cryo-EM
- Barbara Jusiak, firstname.lastname@example.org, Physiology & Biophysics
My lab combines mammalian synthetic biology and fruit fly (Drosophila) models to study cancer-host interactions and to engineer immune cells against cancer.
- Peter Kaiser, email@example.com, Biological Chemistry
Our lab studies the ubiquitin proteasome pathway, cell cycle, and cancer metabolism, focusing on mechanism of diet/therapeutics interactions and development of mutant p53 reactivation compounds.
- Vladimir Kefalov, firstname.lastname@example.org, Physiology & Biophysics
Functional analysis of rod and cone photoreceptor cells, mechanisms of light- and dark-adaptation, and photoreceptor degeneration and visual disorders
- Philip Kiser, email@example.com, Physiology & Biophysics
Physiology and structural biology of the first steps of vertebrate vision, retinoid and carotenoid metabolism, retinal disease and therapeutics.
- Mei Kong, firstname.lastname@example.org, Molecular Biology & Biochemistry
Nutritional microenvironment in tumor development and drug response, metabolism, epigenetics and cancer stem cells, protein phosphatase regulation in diabetes and obesity.
- Orkide Koyuncu, email@example.com, Microbiology & Molecular Genetics
In the Koyuncu lab, we study virus infections of the nervous system with a focus on local and global changes in neuronal biology during alpha herpesvirus infection
- Evgeny Kvon, firstname.lastname@example.org, Developmental & Cell Biology
The Kvon lab investigates mammalian gene regulation using cutting-edge genomics, genome editing, and transgenic tools. We are particularly interested in studying the role of gene regulation in development and evolution and how its malfunction leads to congenital disease
- Young Jik Kwon, email@example.com, Molecular Biology & Biochemistry
Gene therapy, Nanomedicine, Cancer vaccines, Cell therapy
- Albert La Spada, firstname.lastname@example.org, Pathology & Laboratory Medicine
Our research seeks the mechanisms that underlie neurodegeneration and neuron cell death in spinal & bulbar muscular atrophy, spinocerebellar ataxia type 7, Huntington’s Disease, ALS, Parkinson’s disease, and Alzheimer’s disease, and by reproducing molecular pathology in mice and in neurons, astrocytes, and skeletal muscle cells derived from human patient stem cells, we are developing therapies to treat these diseases.
- Arthur Lander, email@example.com, Developmental & Cell Biology
We study the Systems Biology of growth, development, birth defects and cancer. Mathematical and computational approaches are used extensively.
- Thomas E. Lane, firstname.lastname@example.org, Neurobiology & Behavior
The focus of the laboratory is to evaluate underlying molecular and cellular mechanisms contributing to neuroinflammation, neurodegeneration, and repair in pre-clinical models of neurologic disease.
- Pablo Lara-Gonzalez, email@example.com, Developmental & Cell Biology
Molecular pathways that ensure accurate chromosome segregation in mitosis and their intersection with embryonic development; entry and exit from quiescence in response to nutrient signaling.
- Devon A. Lawson, firstname.lastname@example.org, Physiology & Biophysics
Cellular, molecular and genomic mechanisms of breast cancer metastasis
- Wei Ling Lau, email@example.com, Physiology & Biophysics
Vascular injury and gut dysbiosis in chronic kidney disease
- Gina Lee, firstname.lastname@example.org Microbiology & Molecular Genetics
Elucidate oncogenic signaling pathways that rewire cellular metabolism, RNA biogenesis and RNA epigenetic modification in human cancer
- Han Li, email@example.com, Biological Chemistry
Engineering of enzymes and microbes for health, sustainability, and environment.
- Wei Li, firstname.lastname@example.org, Biological Chemistry
Computational Biomedicine: Epigenetics Liquid Biopsy and Alternative Polyadenylation Therapy
- Chang Liu, email@example.com, Molecular Biology & Biochemistry
What does the map between macromolecular sequence and function look like? How does a gene’s evolutionary past shape its future?
- Haoping Liu, firstname.lastname@example.org, Biological Chemistry
We study the human fungal pathogen Candida albicans, Candida-host cell interaction, mechanisms of pathogenesis and drug resistance.
- Melissa Lodoen, email@example.com, Molecular Biology & Biochemistry
My research program is focused on the innate immunity, neuroinflammation, and host-pathogen interactions during infection with Toxoplasma gondii.
- Ulrike Luderer, firstname.lastname@example.org, Developmental & Cell Biology
We investigate mechanisms by which prenatal and postnatal exposures to toxic chemicals and ionizing radiation disrupt reproductive function and cause ovarian cancer.
- Ray Luo, email@example.com, Molecular Biology & Biochemistry
Our research interests are in the general area of computational structural biology and biophysics. We are particularly interested in computational analysis of solvation-mediated electrostatics and polarization effects in molecular recognition and disordered proteins in cancer biology and biosynthesis.
- Andrej Luptak, firstname.lastname@example.org, Molecular Biology & Biochemistry
RNA biology and chemistry
- Grant R. MacGregor, email@example.com, Developmental & Cell Biology
Function of FNDC3 proteins in development, homeostasis and reproduction; Improved mouse models of late-onset Alzheimer’s Disease.
- Francesco Marangoni, firstname.lastname@example.org, Physiology & Biophysics
Study of immune regulation using functional intravital microscopy
- Matthew Marsden, email@example.com, Microbiology & Molecular Genetics
My research is primarily focused on HIV cure efforts and involves molecular analysis of latent HIV together with cellular and animal models of HIV infection.
- Rachel W. Martin, firstname.lastname@example.org, Molecular Biology & Biochemistry
Structural biology and biophysics of both highly soluble proteins and protein aggregates; enzyme discovery; NMR methods development.
- Thomas F. Martinez, email@example.com, Biological Chemistry
Unannotated microprotein discovery and characterization, proteomics, genomics, cell biology, protein biochemistry
- Ivan Marazzi, firstname.lastname@example.org, Biological Chemistry
The Marazzi Laboratory studies epigenetic and chromatin-mediated control of gene expression in the context of the cellular response to pathogens or cellular differentiation.
- Selma Masri, email@example.com, Biological Chemistry
Research in the Masri lab is aimed at understanding the relationship between disruption of circadian rhythms and tumorigenesis, with a major focus on immunology, metabolism and stem cell biology.
- Michael McClelland, firstname.lastname@example.org, Microbiology & Molecular Genetics, Pathology & Laboratory Medicine High-throughput genetics, evolution of Salmonella pathogenesis; bacterial therapy for cancer; cancer genomics and prognostic
- Reggie McNulty, email@example.com, Molecular Biology & BiochemistryMacromolecular assemblies in inflammation and cancer using Cryo-EM and other approaches
- Haik Mkhikian, firstname.lastname@example.org, Pathology & Laboratory Medicine
We study 1) how glycans regulate cell-surface biology, 2) the dysregulation of glycosylation in immune aging, and 3) the development of new methodologies/tools for glycobiology
- Edwin S. Monuki, email@example.com, Pathology & Laboratory Medicine, Developmental & Cell Biology
Modeling and probing the roles and pathologies of the choroid plexus and cerebrospinal fluid on the human brain
- Benjamin R. Morehouse, firstname.lastname@example.org, Molecular Biology & Biochemistry
Studying the evolution and diversification of innate immune signaling systems using biochemical and structural methods. Interested in cyclic nucleotides and chemical defenses.
- Stanley W.K. Ng, email@example.com Biological Chemistry
The Ng Lab uses multiple spatial and omics sequencing technologies to profile tissue clones and assess their contribution to overall disease state, treatment response, and patient outcomes
- Dequina Nicholas, firstname.lastname@example.org, Molecular Biology & Biochemistry
We study chronic inflammation in type 2 diabetes and polycystic ovary syndrome.
- Trina M. Norden-Krichmar, email@example.com, Biological Chemistry
Bioinformatics; genetic factors in human diseases; medical, environmental and marine genomics; computational drug discovery; machine learning
- Shivashankar Othy, firstname.lastname@example.org Physiology & Biophysics
Spatiotemporal Dynamics of Immune Regulation: Decoding Neuro-Immune Interactions, Vaccine Mechanisms, and Mechanosignaling in Immune System
- Krzysztof Palczewski, email@example.com, Molecular Biology & Biochemistry, Physiology & Biophysics
Kris Palczewski’ s laboratory is focused on the fundamental process of vision taking place in rod and cone photoreceptors of the retina and the adjacent pigment epithelium.
- Nicholas Pannunzio, firstname.lastname@example.org, Biological Chemistry
Cancer etiology, cancer genetics, genome integrity, DNA double-strand break repair, and cancer health disparities in underrepresented groups
- Abraham J. Qavi, email@example.com, Pathology & Laboratory Medicine
Development of innovative diagnostic technologies for (re)-emerging pathogens.
- Farah Rahmatpanah, firstname.lastname@example.org, Pathology & Laboratory Medicine
Prostate cancer disparities, ovarian cancer, cervical cancer, bioinformatics, epigenetics
- Olga Razorenova, email@example.com, Molecular Biology & Biochemistry
We focus on kidney and breast cancer. We study tumor suppressors and oncogenes, as well as tumor cell microenvironment (especially hypoxia). We are interested in tumor cell metabolism and metastasis. Our ultimate goal is to find critical molecular targets expressed by cancer cells for therapy design.
- Matt Rose, firstname.lastname@example.org, Pathology & Laboratory Medicine
Mapping gene networks, cell fate, and neural wiring decisions with multi-omics and 3D-cleared and live imaging in neurodevelopment and models of neurologic disease
- Thomas F. Schilling, email@example.com, Developmental & Cell Biology
Our laboratory is generally interested in the early embryonic development of the vertebrate nervous and musculoskeletal systems. We study zebrafish, small teleost fish that have emerged as a powerful new genetic system for studying how genes control early development. The genetic mechanisms we are studying have important implications for human craniofacial birth defects and cancers.
- Donald F. Senear, firstname.lastname@example.org, Molecular Biology & Biochemistry
Interactions of proteins and DNA in transcriptional regulation
- Xiaoyu Shi, email@example.com, Developmental & Cell Biology
We develop super-resolution microscopy and spatial multiomics methods to study aging and cancer at from molecular to organ levels.
- Yongsheng Shi, firstname.lastname@example.org, Microbiology & Molecular Genetics
Our laboratory studies the mechanism and regulation of mRNA processing in development and in pathogen-host interactions.
- Albert Siryaporn, email@example.com, Molecular Biology & Biochemistry
Bacterial pathogenesis, host-microbe interactions, antimicrobials, and biofilm development
- Dorota Skowronska-Krawczyk, firstname.lastname@example.org, Physiology & Biophysics
Skowronska-Krawczyk’s laboratory focuses on understanding the molecular mechanism of aging in the eye and on discovering novel treatments to prevent age-related vision loss.
- Bryan Sun, email@example.com, Biological Chemistry
The Sun Laboratory studies genetic mechanisms of skin tissue development and disease with a particular interest on regulatory elements of the noncoding genome. We use primary cell culture, skin organoids, and human/patient samples for our research.
- Vivek Swarup, firstname.lastname@example.org, Neurobiology & Behavior
Genomics of Neurodegenerative dementia
- E. R. Chulie Ulloa, email@example.com, Microbiology & Molecular Genetics
We investigate novel therapeutic strategies (e.g., immune-based therapies and drug-repurposing) to treat drug-tolerant or -resistant bacterial pathogens.
- Lisa Wagar, firstname.lastname@example.org, Physiology & Biophysics
Translational human immunology, adaptive immunity, organoids, vaccines and infectious diseases
- Katrine Whiteson, email@example.com, Molecular Biology & Biochemistry
The Whiteson lab studies human associated microbial and viral communities. We use metagenomics, metabolomics, microbiology and bioinformatics to answer questions about how microbes and viruses (especially phages!) affect human health.
- Travis Wiles, firstname.lastname@example.org, Molecular Biology & Biochemistry
Wiles Lab research focuses on the form and function of microbiomes, the ecology and evolution of antibiotic resistance, and immune sensing of gut bacterial communities.
- Alvin Yu, email@example.com, Physiology & Biophysics
My lab uses multiscale computational techniques to investigate the molecular mechanisms of disease.