Faculty participating in the Cellular & Molecular Biosciences Program
- Geoff Abbott, abbottg@uci.edu, Physiology & Biophysics
Biology and pharmacology of voltage-gated potassium channels, voltage-independent potassium channels, and ion transporters. - Lauren Albrecht, lvalbrec@uci.edu, Developmental & Cell Biology
- The Albrecht lab investigates the molecular basis of protein methylation as a novel regulator of proteostasis, cell metabolism, and tissue remodeling in cancer. By elucidating new mechanisms of cancer cell metabolism and growth, the studies in our lab aim to generate novel pharmacologic- and diet-based interventions.
- Bogi Andersen, bogi@uci.edu, Medicine and Biological Chemistry
Transcriptional regulation in the developmental biology of epidermis and mammary gland - Rosa Andrade, rmandra1@uci.edu, Microbiology & Molecular Genetics
Toxoplasma gondii, Entamoeba histolytica,Neglected Tropical Diseases and drug discovery. Clinical Interests: HIV and STD management. - Kavita Arora, karora@uci.edu, Developmental & Cell Biology
Drosophila development; TGF-b signal transduction; cell signaling
Regulation of protein function by covalent modification - Scott Atwood, satwood@uci.edu, Developmental & Cell Biology
Cell fate decisions in skin cancer, skin and hair follicle development, and stem cells. - Pierre Baldi, pfbaldi@uci.edu, Computer Science, Biological Chemistry, and Development & Cell Biology
Bioinformatics, computational biology, probabilistic modeling, and machine learning - Tallie Z. Baram, tallie@uci.edu, Physiology & Biophysics
Epigenetic mechanisms in brain plasticity; stress, epilepsy, learning and memory - Lee Bardwell, bardwell@uci.edu, Developmental and Cell Biology
Intracellular signaling in development and disease - Kevin Beier, kbeier@uci.edu, Physiology & Biophysics
Identifying how experience modulates activity dynamics in neural circuits, both acutely and chronically - Claudia Benavente, claudia.benavente@uci.edu, Developmental & Cell Biology
Understanding epigenetic deregulation in pediatric cancer tumorigenesis - Michael W. Berns, mwberns@uci.edu, Developmental & Cell Biology and Surgery
Laser microsurgery of cells, embryos, and tissues - Elizabeth N. Bess, elizabeth.bess@uci.edu, Molecular Biology and Biochemistry
Uncovering chemical reactions encoded in the gut microbiome to understand and treat human disease - Bruce Blumberg, blumberg@uci.edu, Developmental & Cell Biology
Gene regulation by nuclear hormone receptors in vertebrate development & adult physiology Epigenomic analysis of gene-environment interactions - Emiliana Borrelli, borrelli@uci.edu, Microbiology & Molecular Genetics and Pharmacology
Dopaminergic system, with particular focus on dopamine D2 receptors - Daniela Bota, dbota@uci.edu, Neurology and Pathology & Laboratory Medicine
The mechanisms of chemotherapy-induced cognitive damage, and differential mechanisms governing glioma stem cell versus neural stem cell differentiation - Michael J. Buchmeier, m.buchmeier@uci.edu, Molecular Biology & Biochemistry and Medicine
Viral biology and pathogenesis, structural and functional proteomics of viruses, and biodefense related pathobiology - Remi Buisson, rbuisson@uci.edu, Biological Chemistry
Genomic instability, DNA repair and mutagenesis in cancer - Michael D. Cahalan, mcahalan@uci.edu, Physiology & Biophysics
Ion channels in the nervous and immune systems - Anne L. Calof, alcalof@uci.edu, Anatomy & Neurobiology and Developmental & Cell Biology
Regulation of stem cells in development and regeneration; genomic strategies for understanding the etiology and treatment of human neurodevelopmental disorders using transgenic mouse models - Jefferson Y. Chan, jchan@uci.edu, Pathology & Laboratory Medicine
Regulation of genes associated with oxidative stress - John Chaput, jchaput@uci.edu, Molecular Biology & Biochemistry
Expanding the concepts of heredity and evolution to artificial genetic polymers with backbone structures that are distinct from those found in nature - Dongbao Chen, dongbaoc@uci.edu, Obstetrics & Gynecology and Pathology & Laboratory Medicine
Angiogenesis and perinatal vascular biology - Phang Lang Chen, plchen@uci.edu, Cancer Biology and Biological Chemistry
Critical role of tumor suppressor genes in the genesis and progression of cancer - Steven Chessler, s.chessler@uci.edu, Medicine and Pathology & Laboratory Medicine
Cellular and molecular mechanisms underlying insulin secretion, pancreatic islet function, and beta cell failure in diabetes. - Ken W.-Y. Cho, kwcho@uci.edu, Developmental & Cell Biology
Molecular mechanisms of axis specification in Xenopus - Olivier Cinquin, olivier.cinquin@uci.edu , Developmental & Cell Biology
Systems biology of cell differentiation - Olivier Civelli, ocivelli@uci.edu, Pharmacology and Developmental & Cell Biology
Molecular neurobiology, G protein-coupled receptors, peptide neurotransmitters - Melanie Cocco, mcocco@uci.edu, Molecular Biology & Biochemistry
NMR spectroscopy, DNA-binding proteins, membrane proteins, cancer - Xing Dai, xdai@uci.edu, Biological Chemistry
Skin and mammary stem cells, Wnt signaling, chromatin, transcription - Michael Demetriou, mdemetri@uci.edu, Neurology and Microbiology & Molecular Genetics
Molecular biology and glycobiology of T cell dysfunction in autoimmune demyelinating disease - Fangyuan Ding, dingfy@uci.edu, Developmental and Cell Biology Single molecule biology and engineering (such as in situ mapping currently inaccessible RNA, quantifying protein-nucleic acid kinetics in a high-throughput manner), emerging from basic single-cell research to tool developments
- Peter Donovan, pdonovan@uci.edu, Biological Chemistry, Professor of Developmental & Cell Biology
Molecular genetics of germ cell and stem cell development - Timothy Downing, thdownin@uci.edu, Microbiology & Molecular Genetics
Stem cell and tissue engineering, regenerative biology, cell reprogramming, epigenomics, mechanobiology - Aimee Edinger, aedinger@uci.edu, Developmental and Cell Biology
Cancer biology and therapy, intracellular trafficking, obesity, drug development and delivery - Robert Edwards, redwards@uci.edu, Pathology & Laboratory Medicine
Development of colitis and colon cancer using a G-protein mouse model of inflammatory bowel disease - Dae Seok Eom, dseom@uci.edu, Developmental & Cell Biology
Intercellular signaling in stem cells and tissue remodeling - Mark J. Fisher, mfisher@uci.edu, Pathology & Laboratory Medicine.
Mechanisms of cerebrovascular stroke - Angela Fleischman, agf@uci.edu, Medicine and Biological Chemistry
Hematopoietic stem cell biology and leukemia - Donald Forthal, dnfortha@uci.edu, Medicine, Molecular Biology & Biochemistry
Interactions between antibodies and Fc receptors and the role of these interactions in preventing, controlling or enhancing infection with HIV and related lentiviruses. - David A. Fruman, dfruman@uci.edu, Molecular Biology & Biochemistry
Signal transduction in lymphocytes - Anand Ganesan, aganesan@uci.edu, Dermatology and Biological Chemistry
Identify the key molecular regulators of melanin production, melanoma cell survival, and melanoma chemoresistance in human cells - Paul Gershon, pgershon@uci.edu, Molecular Biology & Biochemistry
mRNA transcription and modification - Charles G. Glabe, cglabe@uci.edu, Molecular Biology & Biochemistry
Amyloid Ab peptide in Alzheimer’s pathogenesis; gamete recognition - Alan L. Goldin, agoldin@uci.edu, Microbiology & Molecular Genetics
Molecular analysis of ion channel function - Shane Gonen, gonens@uci.edu, Molecular Biology & Biochemistry
Electron cryo-microscopy (Cryo-EM); Membrane proteins; Protein complexes; Computational protein design - Steven A. Goldstein, sgoldst2@uci.edu, Physiology & Biophysics
Ion channels in health and disease - Celia Goulding, celia.goulding@uci.edu, Molecular Biology & Biochemistry
Structural and biochemical studies of molecular assemblies in Mycobacterium tuberculosis - Michael Green, m.green@uci.edu, Molecular Biology & Biochemistry and Chemistry
Structure-function relationships in metalloproteins, protein engineering, and biological C-H bond activation - Steven Gross, gonens@uci.edu, Developmental & Cell Biology
Laser tweezers; in vivo study of molecular motors - Klemens Hertel, khertel@uci.edu, Microbiology & Molecular Genetics
Regulation of gene expression by alternative splicin - Michael Hicks, mrhicks1@hs.uci.edu, Physiology & Biophysics Skeletal muscle, muscle stem cells, and iPSCs with a focus on regeneration and cell therapies for muscle wasting diseases
- Allon Hochbaum, hochbaum@uci.edu, Molecular Biology and Biochemistry
Biological and bioinspired materials; chemical and biophysical regulation of bacterial biofilms; supramolecular protein assembly - Todd Holmes, tholmes@uci.edu, Physiology & Biophysics
Human neurodegenerative disease mechanisms in transgenic animals - Naoto Hoshi, nhoshi@uci.edu, Pharmacology and Physiology and Biophysics
M-type potassium ion channel regulation through protein complex - Yilin Hu, yilinh@uci.edu, Molecular Biology and Biochemistry Biofuel, activation and reduction of carbon dioxide, structure & function of metalloenzymes involved in methanogenesis, photosynthesis and nitrogen fixation
- Lan Huang, lanhuang@uci.edu, Physiology & Biophysics
Defining the structure and function of protein complexes using cross-linking mass spectrometry and integrative modeling, Proteasomal biology, Ubiquitination, Chemical biology, Quantitative Proteomics, Protein-protein interactions; Regulation of the ubiquitin-proteasome system. - Christopher C.W. Hughes, cchughes@uci.edu, Molecular Biology & Biochemistry
Molecular biology of developmental and tumor angiogenesis - Matt Inlay, minlay@uci.edu, Molecular Biology & Biochemistry
Molecular mechanisms regulating developmental fate decisions in embryonic and adult hematopoiesis in mouse and humans. - Autumn S. Ivy, aivy@uci.edu, Physiology & Biophysics
Role of exercise-induced chromatin modifications in brain plasticity and neural function, early-life periods of brain maturation. - Rongsheng Jin, r.jin@uci.edu, Physiology & Biophysics
Structure and function of synaptic proteins; neurotoxins and receptors; protein complexes; protein-protein and protein-ligand interactions; X-ray crystallography - Barb Jusiak, bjusiak@uci.edu, Physiology and Biophysics
- Development of anti-cancer gene circuits and immune modulation with synthetic biology in mammalian and Drosophila systems
- Peter Kaiser, pkaiser@uci.edu, Biological Chemistry
Cell cycle control; regulation of proteins by ubiquitination - Christina Kenney, mkenney@uci.edu, Pathology
Age-related macular degeneration, AMD, mitochondrial genetics, Keratoconus, KC - Kai Kessenbrock, kkessenb@uci.edu, Biological Chemistry
Microenvironmental Control of Stem Cells and Cancer - Vladimir Kefalov, vkefalov@hs.uci.edu, Physiology & Biophysics Functional analysis of rod and cone photoreceptor cells, mechanisms of light- and dark-adaptation, and photoreceptor degeneration
- Philip Kiser, pkiser@uci.edu, Physiology & Biophysics
Physiology and structural biology of the first steps of vertebrate vision, retinoid and carotenoid metabolism, retinal disease and therapeutics. - Mei Kong, meik1@uci.edu, Molecular Biology & Biochemistry
Nutritional microenvironment in tumor development and drug response, metabolism and epigenetics, protein phosphatase regulation in diabetes and obesity - Orkide Koyuncu, okoyuncu@hs.uci.edu, Microbiology and Molecular Genetics Virus infections of the nervous system, and understanding the molecular mechanisms of alpha herpesvirus (HSV, PRV, VZV) invasion, latency establishment and reactivation in the peripheral nervous system neurons
- Young Jik Kwon, kwonyj@uci.edu, Molecular Biology & Biochemistry, Pharmaceutical Sciences, Chemical Engineering & Materials Science, and Biomedical Engineering
Cancer-targeted therapeutics, Engineered viral vectors for gene therapy, Cancer Vaccine - Arthur D. Lander, adlander@uci.edu, Developmental & Cell Biology
Mechanisms of growth factor action; extracellular matrix; developmental neurobiology; systems biology - Thomas E. Lane, tlane@uci.edu, Molecular Biology & Biochemistry
Defining the molecular and cellular mechanisms that contribute to both host defense and disease following viral infection of the central nervous system (CNS) - Devon Lawson, dalawson@uci.edu, Physiology & Biophysics
Mechanisms of Cancer Metastasis - Wei Ling Lau, wllau@uci.edu, Physiology & Biophysics
Vascular calcification, cerebral microbleeds, and chronic inflammation in chronic kidney disease - Chang Liu, ccl@uci.edu, Biomedical Engineering, Chemistry, and Molecular Biology & Biochemistry
Engineered genetic systems for rapid evolution, chemical biology, synthetic biology, and cell biology - Haoping Liu, h4liu@uci.edu, Biological Chemistry
MAP kinase signal transduction; dimorphic regulation in yeast - Melissa Lodoen, mlodoen@uci.edu, Molecular Biology & Biochemistry
Innate immunity, host-microbe interactions, and immune evasion by Toxoplasma gondii - Ulrike Luderer, uluderer@uci.edu, Medicine, Developmental & Cell Biology and Public Health
Reproductive toxicology, developmental toxicology - Ray Luo, rluo@uci.edu, Molecular Biology & Biochemistry
Computational structural biology, biomolecular recognition and biosynthesis, cancer biology, synthetic biology - Andrej Luptak, aluptak@uci.edu, Pharmaceutical Sciences, Chemistry, and Molecular Biology and Biochemistry
RNA biology and chemistry - Grant MacGregor, gmacg@uci.edu, Developmental & Cell Biology
Gametogenesis in the mouse - Francesco Marangoni, fmarango@uci.edu, Physiology & Biophysics
Identify immune regulatory mechanisms within tumors using functional intravital microscopy (F-IVM), and to counteract them to improve the efficacy of immunotherapies - Matthew Marsden, mdmarsde@hs.uci.edu, Microbiology & Molecular Genetics HIV latency and cure approaches
- Rachel Martin, rachel.martin@uci.edu, Molecular Biology & Biochemistry
Solid state NMR, protein structure, membrane proteins, physical chemistry, chemical biology - Selma Masri, smasri@uci.edu, Biological Chemistry
Cancer and stem cell biology, immune microenvironment, young-onset cancer and circadian clock disruption - Michael McClelland, mmcclell@uci.edu, Microbiology and Molecular Genetics Evolution of Salmonella pathogenesis; bacterial therapy for cancer; cancer genomics and prognostic
- Reginald “Reggie” McNulty, rmcnulty@uci.edu, Molecular Biology & BiochemistryMacromolecular assemblies in inflammation and cancer using Cryo-EM and other approaches
- Alexander McPherson, amcphers@uci.edu, Molecular Biology & BiochemistryMacromolecular crystal growth; X-ray diffraction analysis of protein, nucleic acid and virus crystals; Atomic Force Microscopy studies of biological structures, immunoglobulin structure, virus structure and assembly
- Dan Mercola, dmercola@uci.edu, Pathology & Laboratory MedicineTranslational research in prostatic cancer
- Edwin S. Monuki, emonuki@uci.edu, Pathology & Laboratory Medicine and Developmental & Cell BiologyCerebral cortex development and disease
- Naomi Morrissette, nmorriss@uci.edu, Molecular Biology & BiochemistryGenetic, cell biological and structure-function studies of tubulin and microbutules in Apicomplexan parasites
- Ali Mortazavi, ali.mortazavi@uci.edu, Developmental & Cell BiologyApplications of genomics, computation, and sequencing technologies to the analysis of transcriptional regulation in development
- R. Michael Mulligan, rmmullig@uci.edu, Developmental & Cell Biology and Ecology & Evolutionary BiologyRNA editing in plant mitochondria and chloroplast
- Edward L. Nelson, enelson@uci.edu, Medicine and Molecular Biology & BiochemistryTumor immunology, dendritic cell biology, and anti-tumor immunotherapeutics
- Dequina Nicholas, dequinaa@uci.edu, Molecular Biology & Biochemistry Function and metabolism of immune cells in type 2 diabetes and polycystic ovary syndrome; Biology of lipid antigen presentation and pituitary macrophages
- Trina M. Norden-Krichmar, tnordenk@uci.edu, Epidemiology Bioinformatics, genomic and genetic factors in human health, computational methods
- Michael Parsons, mparson1@uci.edu, Developmental and Cell Biology
Role of stem cells and facultative progenitors in development and regeneration of insulin-producing cells - Medha Pathak, medhap@uci.edu, Physiology & Biophysics
How mechanical forces shape neural stem cells behavior in vitro and in vivo; Transduction of mechanical forces by the Piezo1 ion channel - Nicholas Pannunzio, nrpann@uci.edu, Biological Chemistry
Cancer genetics, genome integrity, and cancer health disparities in underrepresented groups - Eric Perlman, epearlma@uci.edu, Ophthalmology and Physiology & Biophysics
Regulatory role of neutrophils in bacterial and fungal infections - Maksim Plikus, plikus@uci.edu, Developmental & Cell Biology
Stem cells and stem cell niche, Regeneration of tissues and organs, Biological pattern formation, Self-organization, Skin and hair follicles, Adipose tissue, WNT and BMP signaling pathways - Thomas L. Poulos, poulos@uci.edu, Molecular Biology & Biochemistry and Physiology & Biophysics
Protein engineering and crystallography - Jennifer Prescher, jpresche@uci.edu, Chemistry, Molecular Biology & Biochemistry, and Pharmaceutical Sciences
Probing biological systems with chemical tools and noninvasive imaging - Feng Qiao, qiao@uci.edu, Biological Chemistry
Telomeres & telomerase and their roles in cancer and stem cell diseases; Structural, biochemical and molecular genetic analyses of nucleoprotein assemblies - Olga V. Razorenova, olgar@uci.edu, Molecular Biology & Biochemistry
Internal (oncogenes/tumor suppressor genes) and external (tumor microenvironment)
factors regulating tumor progression and metastasis - Markus Ribbe, mribbe@uci.edu, Molecular Biology & Biochemistry, and Chemistry Director, Biofuel Innovation Center
Biofuel, artificial enzymes, assembly & function of enzymes containing complex metal cofactors - Matthew Rose, mfrose@hs.uci.edu, Pathology Mapping gene networks, cell fate, and wiring decisions with multi-omics and 3D imaging in neurodevelopment and neurologic disease
- Hamid M. Said , hmsaid@uci.edu Medicine and Physiology & Biophysics
Cellular and molecular aspects of intestinal transport of water-soluble vitamins - Suzanne B. Sandmeyer, sbsandme@uci.edu, Biological ChemistryMolecular genetics of a position-specific yeast retrovirus-like element
- Rozanne M. Sandri-Goldin, rmsandri@uci.edu,Microbiology & Molecular Genetics
Regulatory functions of a post-transcriptionally acting herpes virus protein - Tom Schilling, tschilli@uci.edu, Developmental & Cell Biology
Skeletal and neural patterning; mutational analysis and molecular genetics in the zebrafish - Bert L. Semler, blsemler@uci.edu, Microbiology & Molecular Genetics
Replication of picornavirus RNAs; RNA-protein and protein-protein interactions - Marcus Seldin, mseldin@uci.edu, Biological Chemistry
Systems genetics approaches to understand metabolism and physiology with a special emphasis on mechanisms of tissue-tissue communication - Donald F. Senear, dfsenear@uci.edu, Molecular Biology & Biochemistry
Interactions of proteins and DNA in transcriptional regulation - Xiaoyu Shi, xiaoyu.shi@ucsf.edu, Developmental & Cell Biology
Interested in developing new in situ multiomics methods, by leveraging Super-resolution Microscopy, Expansion Microscopy and multiomics - Yongsheng Shi, yongshes@uci.edu, Microbiology & Molecular Genetics The role of post-transcriptional gene regulation in stem cells and cancer
- Albert Siryaporn, asirya@uci.edu, Physics & Astronomy and Molecular Biology & Biochemistry Bacterial pathogenesis, mechanical signal transduction, and biofilm development
- Dorota Skowronska-Krawczyk, dorotask@hs.uci.edu, Ophthalmology and Physiology & Biophysics The focus of the lab is to understand the molecular mechanism of aging by studying the processes regulating age-related eye diseases, with an emphasis on coordinated changes in cellular, metabolic and transcriptional programs in conditions such as macular degeneration and glaucoma. Laboratory is a part of the Center for Translational Vision Research
- Robert Spitale, rspitale@uci.edu, Molecular Biology & Biochemistry
Focused at understanding how the flow of genetic information is controlled inside cells and altered to result in disease phenotypes - Christine Suetterlin, suetterc@uci.edu, Developmental & Cell Biology
Golgi and centrosome regulation, host pathogen interactions - Vivek Swarup, vswarup@uci.edu, Neurobiology and Behavior Integrative functional genomics approaches to understand brain function and neurodegenerative diseases
- Ming Tan, mingt@uci.edu, Microbiology & Molecular Genetics, and Medicine
Chlamydia infections: Gene regulation and host pathogen interactions - Andrea J. Tenner, atenner@uci.edu, Molecular Biology & Biochemistry and Pathology & Laboratory Medicine
Complement: Molecular basis of neuroinflammation; Alzheimer’s disease - Leslie M. Thompson, lmthomps@uci.edu, Psychiatry, Biological Chemistry, and Neurobiology & Behavior
Molecular and biochemical mechanisms of disease pathogenesis and therapeutic approaches to human neurodegenerative disease - Katherine L Thompson-Peer, ktpeer@uci.edu, Developmental & Cell Biology
Neuronal regeneration after injury; dendrite regeneration - Roberto Tinoco, rtinoco@uci.edu, Molecular Biology & Biochemistry
Adaptive Immune Responses; cellular and molecular mechanisms that promote T cell exhaustion during chronic viral infection and cancer - Francesco Tombola, ftombola@uci.edu, Physiology & Biophysics
Electrical and chemical sensing in excitable cells, VSD-containing ion channels and enzymes - Sheryl Tsai, sctsai@uci.edu, Molecular Biology & Biochemistry
Drug design and crystallography of protein complexes - Armando Villalta, armando.villalta@uci.edu, Physiology and Biophysics
Immune cell and organ system interactions that promote tissue injury and repair - Lisa Wagar, lwagar@hs.uci.edu, Physiology & Biophysics How microenvironments within lymphoid tissues regulate the adaptive immune response to infectious diseases and vaccines
- Craig Walsh, cwalsh@uci.edu, Molecular Biology & Biochemistry
Apoptotic mechanisms in immune development and homeostasis - Ping Wang, phwang@uci.edu, Medicine, Biological Chemistry, Physiology & Biophysics, and Pathology & Laboratory Medicine
Molecular hormone actions in diseases and stem cells - Wenqi Wang, wenqiw6@uci.edu, Developmental & Cell Biology
Signaling network in organ size control and cancer development - Rahul Warrior, rwarrior@uci.edu, Developmental & Cell Biology
Developmental regulation of proteoglycan biosynthesis; Transcriptional response to BMP growth factor signaling - Momoko Watanabe, momokow@uci.edu, Anatomy & Neurobiology Human brain organoids as a model system for neural development and disease
- Marian L. Waterman, mlwaterm@uci.edu, Microbiology & Molecular Genetics
Regulation of gene expression in development and cancer - Gregory Weiss, gweiss@uci.edu, Chemistry and Molecular Biology & Biochemistry and Pharmaceutical Sciences
Engineering and dissection of protein structure and function - Katrine Whiteson, katrine@uci.edu, Molecular Biology & Biochemistry
Metagenomics, metabolomics and community culture models of host-associated microbial and viral communities in health and disease; human microbiome; microbial ecology. - Xiaohui Xie, xhx@ics.uci.edu, Computer Science and Developmental & Cell Biology
Computational biology, bioinformatics, and genomics - Qin Yang, qiny3@uci.edu, Medicine and Physiology & Biophysics
Cellular and molecular mechanisms for insulin resistance and energy expenditure in obesity and type 2 diabetes - Kyoko Yokomori, kyokomor@uci.edu, Biological Chemistry,
- Chromatin Structure Regulation in Human ES Cells; Gene expression and chromatin structure
- Michael Zaragoza, mzaragoz@uci.edu, Biological Chemistry and PediatricsMolecular mechanisms of inherited cardiovascular diseases
- Weian Zhao, weianz@uci.edu, Biological Chemistrycancer and developmental mechanobiology, stem cell and immuno-therapy, and microbial genetics
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