The faculty members with an immunology research focus seek to define and understand how the immune system effectively prevents disease by microbial infection or oncogenic transformation, while at the same time avoids damaging self-tissues. Many are using this knowledge to develop novel and effective disease prevention and therapeutic measures. The students enrolled in the immunology program will gain a thorough understanding of these processes in humans as well as in comparative animal models. The training includes recommended course work and research rotations in the laboratories of associated investigators, in addition to an Immunology Journal Club and weekly Seminars in Immunology hosted by the Institute for Immunology. Student fellowship opportunities are available through several NIH-sponsored training grants.
The Biology of Infectious Disease research interest group encompasses diverse experimental systems, including parasites, bacteria, fungi, viruses and disease vectors. The faculty members present a multi-disciplinary approach to the study of infectious disease and microbial pathology. Faculty research involves the study of bacterial pathogens such asBorrelia and Chlamydia, the protozoan agents of malaria, toxoplasmosis and sleeping sickness (Plasmodium, Toxoplasma and Trypanosoma), the viral pathogens Dengue virus and HIV, and the tick (Ixodes) and mosquito (Anopheles and Aedes) insect vectors that spread human pathogens that cause malaria, Lyme disease and Dengue fever.
- Rosa M. Andrade, firstname.lastname@example.org, Microbiology & Molecular Genetics
Understanding the Redox homeostasis of Toxoplasma gondii to find new therapeutic targets
- Elizabeth N. Bess, email@example.com, Molecular Biology & Biochemistry
Uncovering chemical reactions encoded in the gut microbiome to understand and treat human disease
- Thomas Burke, firstname.lastname@example.org, Microbiology & Molecular Genetics
We study bacterial pathogenesis and the host innate immune response to infection. We’re also targeting innate immunity as a strategy to treat cancer.
- Nir Drayman, email@example.com, Molecular Biology & Biochemistry
Studies how cell-to-cell variability affects viral infection outcomes using technologies such as live-imaging, machine learning, single-cell RNA-sequencing and microfluidics
- Philip L. Felgner, firstname.lastname@example.org, Physiology & Biophysics
The UCI Vaccine R&D Center is supported by the NIH to develop vaccine and vaccine adjuvants for infectious diseases. There is an emphasis on Pandemic Preparedness. The lab is equiped with all of the science, equipment and know-how to construct and test lipid nanoparticle (LNP) vaccines of the kind that are in the COVID vaccines from Moderna and BioNTech. The same mRNA/LNP technology developed for the COVID vaccine is also applicable to gene therapy and gene editing.
- Don Forthal, email@example.com, Molecular Biology & Biochemistry, Pathology & Laboratory Medicine
My laboratory focuses on understanding how antibodies interact with cells bearing Fc receptors (such as macrophages, monocytes, NK cells) and how such interactions affect viral infection. We are interested both in ways that antibodies protect from infection and in ways that antibodies participate in immunopathology.
- Matthew Griffin, firstname.lastname@example.org, Molecular Biology & Biochemistry
Our lab focuses on understanding the molecular mechanisms underlying host-microbiota interactions during cancer progression and treatment.
- Matthew Arthur Kalani Inlay, email@example.com, Molecular Biology & Biochemistry
The biology, development, and therapeutic use of hematopoietic stem cells in blood and marrow transplantation, and the role of the immune system in graft tolerance and graft-versus-host disease.
- Orkide Koyuncu, firstname.lastname@example.org, Microbiology & Molecular Genetics
In the Koyuncu lab, we study virus infections of the nervous system with a focus on local and global changes in neuronal biology during alpha herpesvirus infection
- Thomas E. Lane, email@example.com, Neurobiology & Behavior
The focus of the laboratory is to evaluate underlying molecular and cellular mechanisms contributing to neuroinflammation, neurodegeneration, and repair in pre-clinical models of neurologic disease.
- Haoping Liu, firstname.lastname@example.org, Biological Chemistry
We study the human fungal pathogen Candida albicans, Candida-host cell interaction, mechanisms of pathogenesis and drug resistance.
- Melissa Lodoen, email@example.com, Molecular Biology & Biochemistry
My research program is focused on the innate immunity, neuroinflammation, and host-pathogen interactions during infection with Toxoplasma gondii.
- Francesco Marangoni, firstname.lastname@example.org, Physiology & Biophysics
Study of immune regulation using functional intravital microscopy
- Matthew Marsden, email@example.com, Microbiology & Molecular Genetics
My research is primarily focused on HIV cure efforts and involves molecular analysis of latent HIV together with cellular and animal models of HIV infection.
- Michael McClelland, firstname.lastname@example.org, Microbiology & Molecular Genetics, Pathology & Laboratory Medicine
High-throughput genetics, evolution of Salmonella pathogenesis; bacterial therapy for cancer; cancer genomics and prognostic
- Dequina Nicholas, email@example.com, Molecular Biology & Biochemistry
We study chronic inflammation in type 2 diabetes and polycystic ovary syndrome.
- Shivashankar Othy, firstname.lastname@example.org Physiology & Biophysics
Spatiotemporal Dynamics of Immune Regulation: Decoding Neuro-Immune Interactions, Vaccine Mechanisms, and Mechanosignaling in Immune System
- Abraham J. Qavi, email@example.com, Pathology & Laboratory Medicine
Development of innovative diagnostic technologies for (re)-emerging pathogens.
- Albert Siryaporn, firstname.lastname@example.org, Molecular Biology & Biochemistry
Bacterial pathogenesis, host-microbe interactions, antimicrobials, and biofilm development
- Andrea J. Tenner, email@example.com, Molecular Biology & Biochemistry and Pathology & Laboratory Medicine
Innate immunity; the roles of complement and phagocytes in health and disease
- E. R. Chulie Ulloa, firstname.lastname@example.org, Microbiology & Molecular Genetics
We investigate novel therapeutic strategies (e.g., immune-based therapies and drug-repurposing) to treat drug-tolerant or -resistant bacterial pathogens.
- Lisa Wagar, email@example.com, Physiology & Biophysics
Translational human immunology, adaptive immunity, organoids, vaccines and infectious diseases
- Craig M. Walsh, firstname.lastname@example.org, Molecular Biology & Biochemistry
T cell tolerance, autoimmunity, stem cells, multiple sclerosis, Alzheimer’s disease
- Travis Wiles, email@example.com, Molecular Biology & Biochemistry
Wiles Lab research focuses on the form and function of microbiomes, the ecology and evolution of antibiotic resistance, and immune sensing of gut bacterial communities.
Faculty – Secondary Affiliation
- Remi Buisson, firstname.lastname@example.org, Biological Chemistry
The ongoing research program in the laboratory focuses on unexplored aspects of cellular transcription and translation regulation associated with viral infections and DNA damage.
- Minji Byun, email@example.com, Microbiology & Molecular Genetics
Epigenetic modulator dysfunction in human developmental and immune disorders
- Karina S. Cramer, firstname.lastname@example.org, Neurobiology & Behavior
Our lab studies molecular and cellular mechanisms needed for assembly of neural circuits. We are currently focused on axon guidance mechanisms and on the roles of glial cells.
- Aimee Edinger, email@example.com, Developmental & Cell Biology
Understanding endolysosomal trafficking and sphingolipid biology and translating these discoveries into new therapies for cancer, obesity, and other diseases
- David Fruman, firstname.lastname@example.org, Molecular Biology & Biochemistry
The focus of research in the Fruman Lab is targeted therapies to modulate signaling and metabolism in lymphocytes and leukemia cells.
- Paul Gershon, email@example.com, Molecular Biology & Biochemistry
Mechanistic and structural characterization of vaccinia viral proteins, with an emphasis on specific mRNA synthetic and modification enzymes, using mass spectroscopy, atomic force microscopy and crystallography
- Celia Goulding, firstname.lastname@example.org, Molecular Biology & Biochemistry
We are deciphering iron acquisition in Mycobacterium tuberculosis informed by structural and chemical biology, and proteomics. We are also working on contact-dependent growth inhibition systems (CDI), and the structural basis of its mechanism of action.
- Chris Halbrook, email@example.com, Molecular Biology & Biochemistry
My lab is primarily focused on understanding mechanisms that support cancer development and resistance to therapy.
- Allon Hochbaum, firstname.lastname@example.org, Molecular Biology & Biochemistry
Structural biology and biochemistry of bacterial cytochrome polymers; metabolism and metabolic heterogeneity in bacterial populations and communities.
- Rongsheng Jin, email@example.com, Physiology & Biophysics
Structure and function of bacterial toxins and receptors; synaptic proteins; protein complexes; protein-protein and protein-ligand interactions; X-ray crystallography; Cryo-EM
- Barbara Jusiak, firstname.lastname@example.org, Physiology & Biophysics
My lab combines mammalian synthetic biology and fruit fly (Drosophila) models to study cancer-host interactions and to engineer immune cells against cancer.
- Young Jik Kwon, email@example.com, Molecular Biology & Biochemistry
Gene therapy, Nanomedicine, Cancer vaccines, Cell therapy
- Devon A. Lawson, firstname.lastname@example.org, Physiology & Biophysics
Cellular, molecular and genomic mechanisms of breast cancer metastasis
- Han Li, email@example.com, Biological Chemistry
Engineering of enzymes and microbes for health, sustainability, and environment.
- Anthony D. Long, firstname.lastname@example.org, Ecology & Evolutionary Biology
Population genetics, the genetics of complex traits, the genetics of adaptation, and bioinformatics
- Jennifer Martiny, email@example.com, Ecology & Evolutionary Biology
We study the evolutionary and ecological mechanisms that generate and maintain microbial diversity and how this variation affects functioning of microbial communities (microbiomes).
- Ivan Marazzi, firstname.lastname@example.org, Biological Chemistry
The Marazzi Laboratory studies epigenetic and chromatin-mediated control of gene expression in the context of the cellular response to pathogens or cellular differentiation.
- Selma Masri, email@example.com, Biological Chemistry
Research in the Masri lab is aimed at understanding the relationship between disruption of circadian rhythms and tumorigenesis, with a major focus on immunology, metabolism and stem cell biology.
- Reggie McNulty, firstname.lastname@example.org, Molecular Biology & Biochemistry
Macromolecular assemblies in inflammation and cancer using Cryo-EM and other approaches
- Haik Mkhikian, email@example.com, Pathology & Laboratory Medicine
We study 1) how glycans regulate cell-surface biology, 2) the dysregulation of glycosylation in immune aging, and 3) the development of new methodologies/tools for glycobiology
- Benjamin Morehouse, firstname.lastname@example.org, Molecular Biology & Biochemistry
Studying the evolution and diversification of innate immune signaling systems using biochemical and structural methods. Interested in cyclic nucleotides and chemical defenses.
- Yongsheng Shi, email@example.com, Microbiology & Molecular Genetics
Our laboratory studies the mechanism and regulation of mRNA processing in development and in pathogen-host interactions.
Katrine Whiteson, firstname.lastname@example.org, Molecular Biology & Biochemistry
The Whiteson lab studies human associated microbial and viral communities. We use metagenomics, metabolomics, microbiology and bioinformatics to answer questions about how microbes and viruses (especially phages!) affect human health.
- Alvin Yu, email@example.com, Physiology & Biophysics
My lab uses multiscale computational techniques to investigate the molecular mechanisms of disease.