The faculty members with an immunology research focus seek to define and understand how the immune system effectively prevents disease by microbial infection or oncogenic transformation, while at the same time avoids damaging self-tissues. Many are using this knowledge to develop novel and effective disease prevention and therapeutic measures. The students enrolled in the immunology program will gain a thorough understanding of these processes in humans as well as in comparative animal models. The training includes recommended course work and research rotations in the laboratories of associated investigators, in addition to an Immunology Journal Club and weekly Seminars in Immunology hosted by the Institute for Immunology. Student fellowship opportunities are available through several NIH-sponsored training grants.

The Biology of Infectious Disease research interest group encompasses diverse experimental systems, including parasites, bacteria, fungi, viruses and disease vectors.  The faculty members present a multi-disciplinary approach to the study of infectious disease and microbial pathology.  Faculty research involves the study of bacterial pathogens such asBorrelia and Chlamydia, the protozoan agents of malaria, toxoplasmosis and sleeping sickness (PlasmodiumToxoplasma and Trypanosoma), the viral pathogens Dengue virus and HIV, and the tick (Ixodes) and mosquito (Anopheles and Aedes) insect vectors that spread human pathogens that cause malaria, Lyme disease and Dengue fever.

  • Rosa, Microbiology & Molecular Genetics
    Toxoplasma gondii, Entamoeba histolytica,Neglected Tropical Diseases and drug discovery. Clinical Interests: HIV and STD management.
  • Elizabeth N., Chemistry
    Uncovering chemical reactions encoded in the gut microbiome to understand and treat human disease
  • Michael Buchmeier,, Molecular Biology & Biochemistry
    Viral biology and pathogenesis, structural and functional proteomics of viruses, and biodefense related pathobiology
  • Michael D. Cahalan,, Physiology & Biophysics
    T cell activation: ion channels, calcium signaling, and gene expression
  • Michael Demetriou,, Neurology and Microbiology & Molecular Genetics
    Molecular biology and glycobiology of T cell dysfunction in autoimmune demyelinating disease
  • Donald Forthal,, Medicine, Molecular Biology & Biochemistry
    Interactions between antibodies and Fc receptors and the role of these interactions in preventing, controlling or enhancing infection with HIV and related lentiviruses
  • David A. Fruman,, Molecular Biology & Biochemistry
    Signaling pathways controlling lymphocyte activation and differentiation
  • Anthony A. James,, Molecular Biology & Biochemistry and Pathology & Laboratory Medicine
    Malaria parasite development; genetic manipulation of insect vectors
  • Melissa Lodoen,, Molecular Biology & Biochemistry
    Modulation of host immunity by Toxoplasma gondii
  • Francesco Marangoni,,  Physiology & Biophysics
    Identify immune regulatory mechanisms within tumors using functional intravital microscopy (F-IVM), and to counteract them to improve the efficacy of immunotherapies
  • Ilhem Messaoudi,, Molecular Biology & Biochemistry
    Viral pathogenesis, vaccine development, microbiome, modulation of immunity by nutrition
  • Naomi Morrissette,, Molecular Biology & Biochemistry
    Genetic, cell biological and structure-function studies of tubulin and microtubules in Apicomplexan parasites
  • Eric, Ophthalmology and Physiology & Biophysics
    Regulatory role of neutrophils in bacterial and fungal infections
  • A. Olga, Molecular Biology & Biochemistry
    Internal (oncogenes/tumor suppressor genes) and external (tumor microenvironment)
    factors regulating tumor progression and metastasis.
  • Rozanne M. Sandri-Goldin,, Microbiology & Molecular Genetics
    Structure and functional analysis of a multifunction herpes virus regulatory protein
  • Bert L. Semler,, Microbiology & Molecular Genetics
    Replication of picornavirus RNAs; RNA-protein and protein-protein interactions
  • Albert Siryaporn,, Physics & Astronomy and Molecular Biology & Biochemistry
    Bacterial pathogenesis, mechanical signal transduction, and biofilm development
  • Ming Tan,, Microbiology & Molecular Genetics, and Medicine
    Chlamydia infections: Gene regulation and host pathogen interactions
  • Andrea J. Tenner,, Molecular Biology & Biochemistry and Pathology & Laboratory Medicine
    Innate immunity; the roles of complement and phagocytes in health and disease
  • Roberto Tinoco,, Molecular Biology & Biochemistry
    Adaptive Immune Responses; cellular and molecular mechanisms that promote T cell exhaustion during chronic viral infection and cancer
  • Armando, Physiology and Biophysics
    Immune cell and organ system interactions that promote tissue injury and repair
  • Craig M. Walsh,, Molecular Biology & Biochemistry
    Apoptotic mechanisms in immune development and homeostasis 

Faculty – Secondary Affiliation

  • Steve, Ecology & Evolutionary Biology
    Microbial ecology, modeling, and global environmental change
  • Angela Fleischman,, Medicine and Biological Chemistry
  • David A. Fruman,, Molecular Biology & Biochemistry
    Targeting the PI3K/AKT/mTOR pathway in leukemia and lymphoma cells 
  • Paul Gershon,, Molecular Biology & Biochemistry
    Mechanistic and structural characterization of vaccinia viral proteins, with an emphasis on specific mRNA synthetic and modification enzymes, using mass spectroscopy, atomic force microscopy and crystallography
  • Matt Inlay,, Molecular Biology & Biochemistry
    Molecular mechanisms regulating developmental fate decisions in embryonic and adult hematopoiesis in mouse and humans.
  • Rongsheng Jin,, Physiology & Biophysics
    Structure and function of synaptic proteins; neurotoxins and receptors; protein complexes; protein-protein and protein-ligand interactions; X-ray crystallography
  • Haoping Liu,, Biological Chemistry
    MAP kinase signal transduction; dimorphic regulation in yeast
  • Jennifer B.H., Ecology & Evolutionary Biology
    Diversity, evolution, and functioning of microbial communities (microbiomes).
  • Michael McClelland,, Microbiology and Molecular Genetics
    Evolution of Salmonella pathogenesis; bacterial therapy for cancer; cancer genomics and prognostics.
  • Edward L. Nelson,, Medicine and Molecular Biology & Biochemistry
    Tumor immunology, dendritic cell biology, and anti-tumor immunotherapeutics
  • Jennifer Prescher,, Chemistry, Molecular Biology & Biochemistry, and Pharmaceutical Sciences
    Probing biological systems with chemical tools and noninvasive imaging
  • Christine Suetterlin,, Developmental and Cell Biology
    .Chlamydia cell biology
  • Katrine Whiteson,, Molecular Biology & Biochemistry
    Metagenomics, metabolomics and community culture models of host-associated microbial and viral communities in health and disease; human microbiome; microbial ecology.
  • Weian Zhao,, Biological Chemistry and Pharmaceutical Sciences
    Stem cell engineering and clinical translation, molecular sensors and diagnostics, single-cell analysis and screening, cancer immunotherapy