Immunology and Microbiology

About

The faculty members with an immunology research focus seek to define and understand how the immune system effectively prevents disease by microbial infection or oncogenic transformation, while at the same time avoids damaging self-tissues. Many are using this knowledge to develop novel and effective disease prevention and therapeutic measures. The students enrolled in the immunology program will gain a thorough understanding of these processes in humans as well as in comparative animal models. The training includes recommended course work and research rotations in the laboratories of associated investigators, in addition to an Immunology Journal Club and weekly Seminars in Immunology hosted by the Institute for Immunology. Student fellowship opportunities are available through several NIH-sponsored training grants.

The Biology of Infectious Disease research interest group encompasses diverse experimental systems, including parasites, bacteria, fungi, viruses and disease vectors.  The faculty members present a multi-disciplinary approach to the study of infectious disease and microbial pathology.  Faculty research involves the study of bacterial pathogens such asBorrelia and Chlamydia, the protozoan agents of malaria, toxoplasmosis and sleeping sickness (PlasmodiumToxoplasma and Trypanosoma), the viral pathogens Dengue virus and HIV, and the tick (Ixodes) and mosquito (Anopheles and Aedes) insect vectors that spread human pathogens that cause malaria, Lyme disease and Dengue fever.

Matt Inlay
Molecular Biology & Biochemistry

Molecular mechanisms regulating developmental fate decisions in embryonic and adult hematopoiesis in mouse and humans.

minlay@uci.edu

Francesco Marangoni
Physiology & Biophysics

Identify immune regulatory mechanisms within tumors using functional intravital microscopy (F-IVM), and to counteract them to improve the efficacy of immunotherapies

f.marangoni@uci.edu

Matthew Marsden
Microbiology & Molecular Genetics

HIV latency and cure approaches

mdmarsde@hs.uci.edu

Lisa Wagar
Physiology & Biophysics

How microenvironments within lymphoid tissues regulate the adaptive immune response to infectious diseases and vaccines

lwagar@hs.uci.edu

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