Leslie M. Thompson
Molecular and biochemical mechanisms of disease pathogenesis and therapeutic approaches to human neurodegenerative disease
Molecular and biochemical mechanisms of disease pathogenesis and therapeutic approaches to human neurodegenerative disease
Our laboratory is generally interested in the early embryonic development of the vertebrate nervous and musculoskeletal systems. We study zebrafish,
Mapping gene networks, cell fate, and neural wiring decisions with multi-omics and 3D-cleared and live imaging in neurodevelopment and models
Stem cells and stem cell niche, Regeneration of tissues and organs, Biological pattern formation, Self-organization, Skin and hair follicles, Adipose
Our lab aims to understand how the mechanically-activated Piezo1 ion channel regulates neural stem cell fate at molecular, cellular, and
Modeling and probing the roles and pathologies of the choroid plexus and cerebrospinal fluid on the human brain
We investigate mechanisms by which prenatal and postnatal exposures to toxic chemicals and ionizing radiation disrupt reproductive function and cause
We study the pathogenic progression of genetic cardiomyopathies to develop therapeutic strategies for heart failure. Human iPSCs provide the disease
Intrinsic and microenvironmental control of skin and mammary epithelial stem cell function in development and repair/regeneration, and how such control
Using genomics, we study how early cellular differentiation events, particularly in the endodermal lineage leading to an animal’s gut and